Menopause, Cancer & Me

Cancer treatments

In healthcare, all treatments come with risks. For some, these include the potential to cause menopause or make symptoms worse.

Patients and healthcare professionals should consider the level of benefit gained from treatment against the potential side effects

On this page, we look at...

1
Systemic Anti-Cancer Therapy
2
Pelvic radiotherapy
3
Surgical removal of ovaries
4
Hormone therapy

1. Systemic Anti-Cancer Therapy (SACT)

This term describes cancer treatments that use medicines to find and fight cancer cells. Taken as a tablet or given through a drip, SACT helps to stop the cancer from growing or spreading.

The impacts of systemic anti-cancer therapies vary considerably, depending on the person and the treatment. There is a wide range of symptoms with a lot of overlap across different treatments.

“Anyone who is struggling with their symptoms should discuss their treatment and symptom management with their clinical team.”

Chemotherapy

Results in loss of ovarian function in some pre-menopausal patients, with the likelihood increasing with age. Ovarian function may recover once treatment is complete.

Biological therapy/ Immunotherapy

These do not usually produce menopausal symptoms, but are often used alongside other systemic anti-cancer therapies that do.

Endocrine therapy

Ovarian suppression is the only endocrine therapy treatment that leads to menopause. Other endocrine treatments can cause menopausal symptoms.

2. Pelvic radiotherapy

This type of treatment uses high energy rays to destroy cancer cells. It can cause menopause by damaging the ovaries, even when they are not the intended target of the therapy.

Bladder problems

These can be worsened by menopause, or they can increase the effects of symptoms.

Vaginal symptoms

Include vaginal narrowing, shortening and changes to the skin inside the vagina.

For vaginal symptoms, treatment options can include...

3. Surgical removal of ovaries

This term refers to an operation that takes away the ovaries, either on its own or as part of a bigger operation, resulting in sudden menopause. 

Ovarian cancer

There are a variety of reasons for this kind of surgery, including ovarian cancer and the risk that cancer may have spread to the ovaries. There are times when surgery is chosen to remove the hormones produced by the ovaries to improve the outlook for the patient's cancer treatment.

Treatment options

Not everyone who has surgical menopause will need treatment, but there are treatment options available. What can be offered and advised will depend on symptoms, the type of cancer, and other factors, such as other medical conditions and age.

Removal of ovaries

If a patient is not already in natural menopause, surgical removal of the ovaries means they suddenly enter menopause. Some people might find their symptoms are more severe as a result. Removal of ovaries can also lead to lower sex drive, though there are lots of other factors to consider.

Hormone replacement

Some people might be actively encouraged to go on Hormone Replacement Therapy (HRT), such as young cervical or colonic cancer survivors, while others will be advised against it and directed towards other treatment options for their symptoms.

Everyone's experience of surgical menopause is different. Seek guidance and support if you need help to manage your symptoms effectively.

4. Hormone therapies

Used to target cancers that rely on hormones to grow, such as breast and prostate cancers, hormone therapies either block the body's ability to produce hormones, or interfere with how hormones behave within the body.

Tamoxifen

A drug that blocks the effects of oestrogen on ER-positive breast cancers. Although it may produce menopausal symptoms, Tamoxifen does not cause menopause.

 

Zoladex (Goserelin)

A drug mainly given to a small proportion of pre-menopausal women. Zoladex suppresses ovarian function to bring about menopause, but this can be reversed by stopping the drug.

 

Aromatase Inhibitors

One of three types of a drug used with post-menopausal women to lower circulating oestrogen. They may cause the return or worsening of menopausal symptoms.

 

Fulvestrant

A type of hormone therapy used to treat breast cancer that has spread in women. Fulvestrant is primarily used with women who have been through the menopause.